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The diagnosis and classification of chronic kidney disease (CKD) based on estimated glomerular filtration rate (eGFR) is important for secondary disease prevention, medication prescribing, treatment decisions, and timely specialist referrals. Reliable GFR estimation is particularly important for older adults, as they are more likely to be prescribed medications and referred to specialist care for other medical conditions. In Australia, GFR is estimated using the 2009 Chronic Kidney Disease Epidemiology Collaboration equation (CKD‐EPI₂₀₀₉) whenever serum creatinine is assessed. The recently published CKD‐EPI equation update (CKD‐EPI₂₀₂₁) does not adjust estimates for race. Recognising that race is a social and not a biological construct, CKD‐EPI₂₀₂₁ was validated using data from more than 4000 participants (mean age, 57.0 years; standard deviation, 17.4 years) in the United States, where its use is now recommended by the National Kidney Foundation and the American Society of Nephrology.

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Authors: Elisa K Bongetti, Rory Wolfe, James B Wetmore, Anne M Murray, Robyn L Woods, Michelle A Fravel, Mark R Nelson, Nigel P Stocks, Suzanne G Orchard and Kevan R Polkinghorne

Article Type: Research