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Well publicised, rapid onset deaths in previously healthy children from invasive group A streptococcal disease (iGAS) in Australia in recent years have highlighted the emerging burden of iGAS. Here we explore the evidence and knowledge gaps to inform clinicians, public health units and the Australian public regarding iGAS definition and epidemiological trends in Australia.

To target iGAS when a GAS vaccine becomes available, current epidemiology suggests it should be preferentially provided as an infant series with a booster dose during pregnancy, to reduce the burden of puerperal and neonatal sepsis. This schedule would also be optimal to prevent iGAS in Northern Australia where the early onset and lifelong burden of skin infections drive iGAS incidence.

This MJA perspective shares more.

Learning Outcomes

1. Explain key components of the perspective
2. List main findings
3. Recognise the significance of the perspective.

Details

Authors: Thel K Hla, Jeffrey W Cannon, Asha C Bowen and Rosemary Wyber

Article Type: Perspective